and may suggest better for antidiabetic research? 2.45) lined by cuboidal or columnar epithelium may be observed in the glandular stomach (Bertram et al 1996). Animals were submitted to spinal cord contusion at the T8-T9 level by the weight drop method. Arterial thrombosis (not caused by arteritis) occurs occasionally in the lung, kidney, liver and adrenal (Ruben 2000). Mast cells in lymph nodes (Fig. FIGURE 2.11 Plasmacytosis in the mandibular lymph node. ×100. ×200. ×400. Cleft palate is a congenital lesion encountered in the midline of the hard palate of rats (Renne et al 2009). Differences between the commonly used rat strains provided by different breeders (i.e., CD (SD) vs. Harlan Sprague-Dawley … FIGURE 2.40 Mineralization of mucus within the lumen of the nasal turbinates of the rat. Increased extramedullary hematopoiesis is a common lesion in the rat spleen (Fig. FIGURE 2.30 Pleural lung tag on surface of rat lung. The current study was designed to compare the metabolic capabilities of the 2 strains in vitro to enable an assessment of their likely metabolic profiles in vivo.. … 2.44), often containing keratin, are common in the stomach, particularly in the region of the limiting ridge and antral mucosa. Apparent dilatation of alveoli can also occur due to excessive instillation of fixative into the lung at necropsy (Renne et al 2003). ×100. Wistar are because of their vasculature good for stroke and ischemic models. In addition, squamous cysts may also be encountered in the gingiva or associated with the teeth in the oral cavity (. Brown pigmented alveolar macrophages in the rat lung. Adult male P rats (59 th-60 th generation, n=10, Indiana U., IN) weighed 200 g, and Wistar (n=8) and Sprague Dawley (SD, n=14) rats (both from Harlan, IN) weighed 325-350 g upon arrival. 2.8) (particularly the medullary or subscapular sinuses) of the lymph nodes are observed commonly in rats. ×100. 2.28), inflammatory cells and alveolar epithelial hyperplasia are often noted in conjunction with the macrophage aggregates. 2.8) (particularly the medullary or subscapular sinuses) of the lymph nodes are observed commonly in rats. Although aging rats produce many interesting lesions, there are also a number of lesions that occur spontaneously in young animals. Thymic cysts are often lined by squamous cells or ciliated epithelium. Occasionally, small foci of neuroendocrine cells in the lung (Fig. The rat spleen normally has a minimal level of extramedullary hematopoiesis; however, it is very difficult to distinguish between normal and excessive levels of extramedullary hematopoiesis. Sebaceous gland ectopia in the oral cavity is observed at the base of the molar teeth (male rats) and between the upper incisors (Bertram et al 1996). In common with extramedullary hematopoiesis, it is often difficult to distinguish between normal and excessive amounts of hemosiderin. Vaso vasorum in adventitia of a mesenteric artery blood vessel in the rat. Lobund-Wistar rat. This lesion consists of thickening of the tunica media due to hypertrophy of the smooth muscle cells (. Different strains of rat differ in their sensitivity to various compounds and in their incidence of spontaneous tumors. The presence of this deeply eosinophilic solitary cell is often confusing. … . ×100. Congestion is a common background lesion of the spleen and may be linked to the method of euthanasia (. Established in 1925 by Robert Dawley, the original Sprague Dawley rat colony was obtained by Harlan in 1980 through the acquisition of Sprague-Dawley, Inc. Harlan became Envigo in 2015. Medial degeneration is common in the coronary arteries of rats and the affected vessels display enlarged, irregularly arranged and sparse nuclei present in a PAS-positive matrix (Ruben 2000). Mineralized hair, food particles or debris are often present in the ventral pouch of the rat larynx, particularly in older rats and squamous metaplasia may be recorded in the respiratory epithelium overlaying the ventral gland as a spontaneous lesion in male Wistar rats on inhalation studies (Renne et al 2003). the manuscript is focused on plant agrobacterium transient expression systems and plant parthenogenesis-related proteins and responses. FIGURE 2.43 Food accummulation around the molar in the rat oral cavity. Lipofuscin pigment may also be present in the red pulp of older rats (. ×100. In this study, we compared metabolic profiles of Wistar and SD rat hepatocytes from middle (6 months) and old (23 months) age groups. The rat spleen, particularly in female animals, normally has minimal to slight amounts of hemosiderin. Rat strains refer to laboratory rats that have been bred in isolation for generations. These thrombi may be emboli originating from atrial thromboses in older rats. Initially a virus was suggested as the cause (rat respiratory virus) (Albers et al 2009), but recently researchers have demonstrated a correlation between the presence of inflammatory lung lesions and Pneumocystis carinii DNA detected by PCR (Livingston et al 2011). FIGURE 2.12 Russell bodies in a lymph node. This article states that Wistar, Long-Evans, and Sprague-Dawley are outbred stocks. Thanks sir really it will be useful. Severe apoptosis is often observed when animals are placed under severe stress or treated with immunosuppressive drugs (. 2.16) is observed as a background lesion in rats. ×100. This study aimed to investigate differences in the long-term effects of ovariectomy on these two breeds of rats. Our researchers recently completed a two-year study of 130 male and 130 female Envigo RccHan®:WIST (Wistar Han®) rats and compared them to other outbred rats (e.g., Sprague-Dawley®, Fischer 344).Here, we share the results of the study. 2.42) is a congenital lesion generally involving the incisor teeth and it may be related to malocclusion or food impaction (Fig. ×100. Bone marrow atrophy is observed in aging rats and the lesion is characterized by a decrease in hemopoietic cells, an increase in adipocytes and an increase reticular stroma (Frith et al 2000b). FIGURE 2.27 Alveolar histiocyte or macrophage aggregates in the rat lung. Ectopic thymus is often associated with the thyroid glands due to the fact that parathyroid glands arise from the same pharyngeal pouches as the thymus (Stefanski et al 1990). All rights reserved. The crystals may be associated with areas of alveolar hemorrhage (Fig. ×100. The aim of this study was to demonstrate strain-specific differences in VILI in infant Sprague Dawley and Wistar rats. 2.37). A strain, in reference to rodents, is a group in which all members are, as nearly as possible, genetically identical. ×100. Rat lymph node with sinus dilatation. The etiology of this finding is unknown. Small areas of alveolar hemorrhage (Fig. The OFT scores varied depending on the day and the age. The Hsd:Sprague Dawley ® SD rat has a wide array of historical research use including in the field of cardiology. Foci of osseous metaplasia are commonly observed in the lungs of both young and old rats (Renne et al 2009) (Fig. Histologically, Fordyce’s granules are identical to their cutaneous counterpart but are not associated with hair follicles. Moderate amounts of intracellular pigment (generally lipofuscin) are often noted in the medullary area. Differences in age and sex of rats should also be taken into consideration when designing toxicological and experimental studies (Johnson & Gad 2007). 2.36a). Taconic Sprague Dawley rats are often used in studying metabolism . For example sprague and albino don't have not a very good visual acuity compared to long evans; sprague have a nice ability to habituate to water deprivation schedules and are not stressed by + maze task... Also be careful, the three strains don't have the same the same strcture locations within the CNS so if you have to do some neurosurgery, you will have to check the coordinates with pilot groups. what is best among these stains for experiments to investigate" "toxic effects of Copper oxide nanoparticles on the testes and level of testosterone in male rats.""?? 2.4) (Johnson & Gad 2007). A hair embolus within an artery in the rat lung, surrounded by inflammatory cells. ×200. ×100. The rats are maintained as an outbred closed colony. Age-related vascular medial cartilage and mineralization may be encountered in the blood vessels of aging rats (Fig. The inclusions are thought to be proteinaceous and the lesion may also be induced by irritant compounds (Renne et al 2003) (Fig. ×200. ×200. Could anyone comment which are the best graphic designing programs (2D and 3D) used by high impact journals to make colorful scientific illustrations/figures for research articles? ×200. Its main advantage is its calmness and ease of handling. Can any body please tell me about any software/programme which can be used to draw animated pictures like neuron, cell membrane, mitochondria etc for scientific figures. What software can I use to draw scientific diagrams like neurons, cell membranes and mitochondria? The rat spleen, particularly in female animals, normally has minimal to slight amounts of hemosiderin. In order to provide historical and reference data for the research community, several of these articles are outlined below. ×100. Clara cells (Fig. Animal Diet: NIH #31M Rodent Diet. FIGURE 2.8 Macrophages with brown pigment in the mesenteric lymph node. ×10. 2.5). Globule leukocytes are present in the respiratory epithelium of the larynx and trachea in rats (Renne et al 2003, 2009). As the atrophy progresses, the epithelial components of the thymus become more prominent and often form tubular structures (Stefanski et al 1990). The Sprague Dawley® outbred model was developed by Sprague Dawley, Inc. NIH received stock from Sprague Dawley, Inc in 1945. ×100. A strain, according to Webster's, is a group of individuals which share a presumed common ancestry and have clear-cut physiological but not usually morphological distinctions (e.g. Strains with in a bronchiole in the larynx and trachea in rats period do differ between both of! 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